Moringa oleifera and Azadirachta indica Leaves Enriched Diets Mitigate Chronic Oxyfluorfen Toxicity Induced Immunosuppression through Disruption of Pro/Anti-Inflammatory Gene Pathways, Alteration of Antioxidant Gene Expression, and Histopathological Alteration in Oreochromis niloticus

Our goal in this study was to determine the effect of dietary supplementation with Moringa oleifera (M. oleifera), and Azadirachta indica (A. indica) leaves mitigating effects chronic oxyfluorfen (OXY) toxicity on health status, expressions immune antioxidant genes, tissue morphological alterations Oreochromis niloticus. In study, we used 370 healthy O. niloticus (average weight = 25.35 ± 0.29 g). We 70 fish 96 h lethal concentration 50 (LC50) OXY. assigned another 300 into six equal groups five replicates (50 fish/group, 10 fish/replicate) OXY for 60 days. The LC50 6.685 mg/L. Exposure 1/10 (0.668 mg/L) had impacts pathological changes main tissues. addition, oxidant genes were disrupted. Dietary both M. A. efficiently mitigated toxic treated groups. Comparing palliative efficiency indica, results showed that more potent alleviating